Klinik Amisi

Plenhyage XL · Skin regeneration

Tired, dull, scarred skin, signalled to repair itself.

Fine lines, dull skin, scars that stayed. Plenhyage XL signals your skin to repair itself over a short course.

WhatsApp us privately How it works

Your conversation stays between you and our all-female team.

30–45 min per session, incl. numbing
24–48 hours for injection marks to settle
Doctor-led skin assessment before anything
All-female medical team, always

Plenhyage, in one paragraph

Plenhyage at Klinik Amisi is an Italian polynucleotide (PDRN) injectable regenerative biostimulator, designed to support the skin's own repair and renewal over a structured course. A session takes 30 to 45 minutes including numbing, with a typical course of 3 to 4 sessions spaced 3 to 4 weeks apart and periodic maintenance. Downtime is usually mild, with small bumps, redness or pinpoint marks that settle within 24 to 48 hours.

You're not alone

Skin gets tired. That doesn't mean it's done.

Stress, sun, hormones and time all slow the skin's own repair. Most women notice it the same way, with skin that looks dull by afternoon, fine lines that used to disappear overnight, texture and scars that stopped fading.

Your skin still knows how to repair itself. Sometimes it just needs the signal to start.

Does this sound like you?

Plenhyage is made for these exact concerns.

Fine lines and early wrinkles
Dull or tired-looking skin
Acne scars and uneven texture
Loss of firmness and elasticity
Dehydrated skin
Under-eye crepiness and tired eyes
When it's not for you: we don't offer Plenhyage during pregnancy or breastfeeding, with an active infection or cold sores in the treatment area, or with a known allergy to fish or salmon-derived products. Autoimmune, bleeding or clotting conditions need medical clearance first. Our doctor screens all of this at consultation, and will tell you honestly if a different treatment fits better.

Three effects, one session

Formulated by Bioformula, Italy, using salmon-DNA polynucleotides for intelligent skin regeneration.

01 · Repair

Regenerate

Polynucleotides signal your fibroblasts to rebuild collagen and elastin, for regeneration, not just rejuvenation.

02 · Tone

Firm

Restores tissue elasticity for firmer, more toned skin over your course.

03 · Glow

Hydrate

Deep hydration for a radiant, plumper appearance that builds week by week.

Plenhyage product

How it works

A short session. Your skin does the rest.

After topical numbing, our doctor places Plenhyage into the upper layers of the skin in small, controlled steps. The polynucleotides create the ideal environment for fibroblast growth, so collagen, elastin and hydration keep building in the weeks after each session.

Salmon-DNA polynucleotidesPDRN 10–25 mg/mlThree strengths: Thin · Medium · StrongAnti-free-radical actionCE-marked medical device

What recovery really looks like

Your week after treatment.

Same day Walk out, carry on

Small bumps at the injection points are expected. Skip heavy makeup for the rest of the day.

Day 1–2 Let it settle

Bumps soften and redness fades. Avoid strenuous exercise, saunas and very hot showers for 24 hours.

First week Be gentle

Skip strong actives, exfoliants and facial massage for 48 hours. Daily SPF 50+ from day one.

The weeks after It keeps building

Collagen and elastin build gradually, so texture, firmness and glow improve over your course.

A typical course is 3 to 4 sessions spaced 3 to 4 weeks apart. Your doctor plans yours with you at consultation. No fixed packages, no pressure.

Doctor-led, female-led care

Regenerative treatment. In careful hands.

  • Every doctor, nurse and front-desk team member is a woman.
  • A doctor examines your skin and history, including any fish or salmon allergy, before anything is planned.
  • Private consultation rooms. Your visit and details stay discreet.
  • Four branches across the Klang Valley: Bangi, Putrajaya, Shah Alam, KL.
Book a private consultation

Questions, answered plainly

What women ask us most.

What is Plenhyage?
Plenhyage is an Italian injectable polynucleotide (PDRN) biostimulator. Its active ingredient is polydeoxyribonucleotide, derived from salmon DNA, which is positioned as a regenerative signal for the skin rather than a volumising or filling agent.
How is Plenhyage different from a hyaluronic acid skin booster?
A hyaluronic acid skin booster mainly supports hydration and surface smoothness. Plenhyage works through a different mechanism: polynucleotides act as a regenerative signal, prompting fibroblasts in the skin to repair and renew over weeks. Some patients combine the two over time, sequenced by their doctor.
Is the treatment painful?
Topical numbing cream is applied before the session to keep the experience comfortable. Most patients describe mild stinging or pressure during the injections.
How many sessions will I need?
A typical course is 3 to 4 sessions spaced 3 to 4 weeks apart. Maintenance sessions are usually planned afterwards. Your doctor will recommend a specific plan based on your skin assessment.
How quickly will I see a difference?
Polynucleotide treatments tend to act gradually as fibroblast activity is supported over weeks. Many patients describe the most noticeable change in skin quality some weeks after the third session. Individual results vary.
How much does it cost?
Pricing depends on whether you take a single session or a course. Please consult our team for current rates.

Not sure what your skin needs?

Tell us what you've been noticing, in Malay or English. Our team will let you know whether Plenhyage, a different treatment, or simply a consultation is the right first step.

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